A network-level investigation of signalling crosstalk and drug response in aggressive breast cancer CONSTANCE GAYA CREMERS 10.26180/5dc4eb534dbfc https://bridges.monash.edu/articles/thesis/A_network-level_investigation_of_signalling_crosstalk_and_drug_response_in_aggressive_breast_cancer/10270091 This thesis is focused on examining drug resistance mechanisms in an aggressive form of breast cancer. In particular, this work investigates how loss of the tumour suppressor gene PTEN, a common genetic disruption in breast cancer, influences the response to anti-cancer therapies. To achieve this, experimental investigations were combined with mathematical modelling. Research into this area is important as drug resistance is a major challenge and unmet medical need in many cancers, including breast cancer. 2019-11-08 04:13:05 Adaptive resistance mechanisms TNBC breast cancer PTEN network-level signalling crosstalk systems-based approach mathematical modelling MAPK signalling PI3K signalling CRISPR-Cas9 Cancer Cell Biology Biochemistry Molecular Biology