A network-level investigation of signalling crosstalk and drug response in aggressive breast cancer
CONSTANCE GAYA CREMERS
10.26180/5dc4eb534dbfc
https://bridges.monash.edu/articles/thesis/A_network-level_investigation_of_signalling_crosstalk_and_drug_response_in_aggressive_breast_cancer/10270091
This thesis is focused on examining drug resistance mechanisms in an aggressive form of breast cancer. In particular, this work investigates how loss of the tumour suppressor gene PTEN, a common genetic disruption in breast cancer, influences the response to anti-cancer therapies. To achieve this, experimental investigations were combined with mathematical modelling. Research into this area is important as drug resistance is a major challenge and unmet medical need in many cancers, including breast cancer.
2019-11-08 04:13:05
Adaptive resistance mechanisms
TNBC
breast cancer
PTEN
network-level
signalling crosstalk
systems-based approach
mathematical modelling
MAPK signalling
PI3K signalling
CRISPR-Cas9
Cancer Cell Biology
Biochemistry
Molecular Biology