%0 Thesis %A KAISER, AHSANUL %D 2019 %T Smart Drug Delivery And Image-Guided Therapy for Cancer with Modified Carbonate Apatite Nanoparticles %U https://bridges.monash.edu/articles/thesis/Smart_Drug_Delivery_And_Image-Guided_Therapy_for_Cancer_with_Modified_Carbonate_Apatite_Nanoparticles/10000001 %R 10.26180/5dad4552e031a %K Photothermal Therapy (PTT) %K pH Responsive %K Theranostic Nanoparticles %K Smart Drug Delivery System (SDDS) %K In Vivo Brain Imaging %K Biomedical Engineering not elsewhere classified %K Nanomedicine %X Nanoparticles-based drug delivery research that led to a promising and viable technology platform has been accepted as an alternative drug delivery system to reduce limitations of the conventional chemotherapy. Recently, inorganic biodegradable pH-sensitive carbonate apatite (CA), a potential drug nanocarrier have been shown to confer great advantages to carry the anti-cancer drugs as well as genetic materials in an efficient and targeted manner. Here we present a different fabrication approach for CA modified with Barium salt as a typical entity of therapeutic importance to reduce the complex diameter and thus to increase the payload capacity for enhanced intracellular transport of different types of therapeutics, such as synthetic anti-cancer drug (DOX, doxorubicin) and co-delivery of ICG and DOX to cancer cell lines. %I Monash University